we[1] operate out of `us-east-1` but chose to not use any of the cloud based vendor lockin (sorry vercel, supabase, firebase, planetscale etc). Rather a few droplets in DigitalOcean(us-east-1) and Hetzner(eu). We serve 100 million requests/mo, few million user generated content(images)/mo at monthly cost of just about $1000/mo.

It's not difficult, it's just that we engineers chose convenience and delegated uptime to someone else.

[1] - https://usetrmnl.com